Protein Engineering Scientist

  • Full Time
  • Boston, MA, USA
  • Job Location Type: In Office Full Time
  • Full Time
  • Boston, MA, USA
  • Job Location Type: In Office Full Time

Fortune 500 Corp

Protein Engineering Scientist – Drug Discovery

We are seeking a talented and highly motivated Protein Engineering Scientist to join our dynamic research team focused on drug discovery. As a Protein Engineering Scientist, you will play a crucial role in designing, executing, analyzing, and interpreting experiments related to synthetic library design and high-throughput screening for novel drug candidates. This position offers an exciting opportunity to contribute to cutting-edge research in the field of protein/enzyme engineering and drive innovations that have a direct impact on drug development.


Protein Engineering and Design: Utilize your expertise in protein engineering to design novel variants with enhanced properties for drug discovery projects.
Synthetic Library Design: Develop diverse and high-quality synthetic libraries tailored to specific drug targets, enabling efficient screening of potential therapeutic candidates.
High-Throughput Screening: Plan and execute high-throughput screening assays to identify and evaluate promising candidates from the synthetic libraries.
Experiment Execution: Independently perform experiments, including protein expression, purification, and characterization, as well as enzymatic assays and binding studies.
Data Analysis and Interpretation: Analyze experimental data using various statistical and bioinformatics tools. Interpret results and draw meaningful conclusions to guide project direction.
Collaboration: Work closely with cross-functional teams, including medicinal chemists, bioinformaticians, and computational scientists, to drive collaborative drug discovery efforts.
Innovation: Stay updated with the latest advancements in protein engineering and high-throughput screening technologies to propose and implement innovative approaches.
Documentation and Reporting: Maintain detailed laboratory notebooks, generate technical reports, and present findings to the research team and management.
Quality Control: Ensure the accuracy, reproducibility, and reliability of experimental procedures through rigorous quality control measures.


  • Ph.D. in Biochemistry, Molecular Biology, Protein Engineering, or a related field with a focus on drug discovery.
  • Proven experience in executing high-throughput screens and/or protein/enzyme engineering work in an industry or academic setting.
  • Strong expertise in protein engineering techniques, including rational design, directed evolution, and library generation.
  • Demonstrated experience in synthetic library design for protein engineering or drug discovery applications.
  • Proficiency in protein expression and purification techniques, as well as enzymatic assays and binding studies.
  • Hands-on experience with high-throughput screening platforms and data analysis tools.
  • Familiarity with computational tools and bioinformatics analysis related to protein engineering is a plus.
  • Ability to work independently and collaboratively in a fast-paced and dynamic research environment.
  • Excellent problem-solving and critical-thinking skills to troubleshoot and optimize experimental protocols.
  • Effective communication skills to present complex scientific concepts and results to both technical and non-technical audiences.

Join our innovative team of researchers and work on exciting projects at the forefront of drug discovery and protein engineering. We look forward to reviewing your application and potentially having you onboard to drive scientific breakthroughs in our organization.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or any other protected factor.

Base Salary Max:: 175000

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Fortune 500 Corp

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